Set both to "Disabled." These effects are often visually disruptive at low frame rates and consume extra processing power.

. While it smooths edges, it can be a performance hog on older cards. Volumetrics/Clouds:

Cities: Skylines easily eats up 16GB of RAM. If your system only has 8GB, the game will crash. Forcing Windows to use your hard drive space as temporary memory (a Page File) prevents these crashes. Type into your Windows search bar.

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Note: Only use -noWorkshop if you want to play a completely vanilla game without any mods or custom assets, as this drastically frees up system memory. Close Background Apps